Critical 10.0HealthcarePublished Jun 24, 2022

CVE-2022-15183.2.2 IMPROPER LIMITATION OF A PATHNAME TO A RESTRICTED DIRECTORY ('PATH TRAVERSAL') CWE-22

Updated under an hour ago (Oct 26, 2026, 3:10 PM ET)

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It affects Illumina NextSeq 550Dx and 7 other products. Add what you run to find out whether that includes you.

EPSS puts the chance of exploitation in the next 30 days at 1.67%, higher than 77% of scored CVEs.

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Every CVE for Illumina NextSeq 550Dx

Exploited in the last 30 days

LRM contains a directory traversal vulnerability that can allow a malicious actor to upload outside the intended directory structure.

CVSS: 10.0 CRITICAL (v3.1, CNA)CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:C/C:H/I:H/A:H
Weakness (CWE): CWE-22
Known exploited: Not in CISA's KEV catalog
EPSS (exploitation in the next 30 days): 1.67% (percentile 77)
Assigned by: icscert
NVD analysis: Modified
Record last updated: Apr 16, 2025
First seen by InfoSec Signals: Oct 12, 2026

Affected products

Affected products

Illumina NextSeq 550Dx illumina:nextseq_550dx (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina MiSeq Dx illumina:miseq_dx (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina NextSeq 500 Instrument illumina:nextseq_500_instrument (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina NextSeq 550 Instrument illumina:nextseq_550_instrument (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina MiSeq Instrument illumina:miseq_instrument (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina iSeq 100 Instrument illumina:iseq_100_instrument (from the name)	LRM Versions 1.3 to 3.1	CNA record
Illumina MiniSeq Instrument illumina:miniseq_instrument (from the name)	LRM Versions 1.3 to 3.1	CNA record
illumina local_run_manager illumina:local_run_manager	from 1.3 through 3.1	NVD

References

References

https://www.cisa.gov/uscert/ics/advisories/icsa-22-153-02	x-refsource-misc, third-party-advisory, us-government-resource

The CVE record on cve.org NVD's entry

The CVE record is authoritative. Products marked “from the name” were identified from the CNA's free-text names, not a CPE, and are matched less certainly. This product uses the NVD API but is not endorsed or certified by the NVD.