Medium 4.3Published Nov 9, 2025

CVE-2025-12921OpenClinica Community Edition CRF Data Import ImportCRFData xml injection

Updated under an hour ago (Oct 27, 2026, 5:50 PM ET)

Does this affect you?

It affects OpenClinica Community Edition and 1 other product. Add what you run to find out whether that includes you.

No exploitation reported and no EPSS estimate yet.

Do this next

Start free and add your stack

Free account, 1 product

Every CVE for OpenClinica Community Edition

Exploited in the last 30 days

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

CVSS: 4.3 MEDIUM (v3.1, CNA)CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:U/C:L/I:N/A:N/E:P/RL:X/RC:R
Weakness (CWE): CWE-91, CWE-74
Known exploited: Not in CISA's KEV catalog
EPSS (exploitation in the next 30 days): Not loaded for this CVE
Assigned by: VulDB
NVD analysis: Analyzed
Record last updated: Nov 14, 2025
First seen by InfoSec Signals: Oct 9, 2026

Affected products

Affected products

OpenClinica Community Edition openclinica:community_edition (from the name)	3.0; 3.1; 3.2; 3.3; 3.4; 3.5; 3.6; 3.7; and 9 more ranges	CNA record
openclinica openclinica openclinica:openclinica	3.12.2; 3.13	NVD

References

References

https://vuldb.com/?id.331641	vdb-entry, technical-description, third-party-advisory
https://vuldb.com/?ctiid.331641	signature, permissions-required, vdb-entry
https://vuldb.com/?submit.680872	third-party-advisory, vdb-entry
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md	related, exploit, third-party-advisory
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc	exploit, third-party-advisory

The CVE record on cve.org NVD's entry

The CVE record is authoritative. Products marked “from the name” were identified from the CNA's free-text names, not a CPE, and are matched less certainly. This product uses the NVD API but is not endorsed or certified by the NVD.